After the outbreak of COVID-19 – a virus constituting a genuinely worldwide risk – fear internationalised in just a few weeks. As the COVID crisis has profoundly shaken societies on a global scale it has contributed to a reconfiguration – perhaps a multiplication – of risks and their perceptions. While foremost constituting a biological hazard, the pandemic has large repercussions on other types of risks, ranging from long-term economic and digital disruption to psychological distress and political confrontation. The nature and frontiers of risks are thus moving as the multilateral system, the most adequate framework to deal with global risks, is ailing and current risk mitigation strategies are increasingly put to question. The six articles of the present Dossier explore these changing hierarchies of risk and the underpinning structural issues that endanger our existence.